Can diet modulate trimethylamine N oxide (TMAO) production? What do we know so far? European Journal of Nutrition Springer Nature Link Trimethylamine N oxide (TMAO) is a small molecule produced in humans primarily by the gut liver axis and has become an important biomarker, and possible mediator, of cardiometabolic and renal disease. Dietary choline, phosphatidylcholine ( Full article: Gutheart axis: emerging therapies targeting trimethylamine N oxide production The anti atherogenic bioactive metabolites of natural medicine generated by host microbe co metabolism system. The terminal metabolites of low bioavailable polysaccharides are SCFAs, among which propionate and butyrate can effectively attenuate