Sanghuangporus sanghuang Mycelium Prevents Paracetamol Induced Hepatotoxicity through Regulating the MAPK NF B, Keap1 Nrf2 HO 1, TLR4 PI3K Akt, and CaMKK LKB1 AMPK Pathways and Suppressing Oxidative Stress and Inflammation Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect