Melanotan What It Is and Its Relation to Skin Cancer Is melanotan II (afamelanotide) safe to use for skin darkening? We are alerting the public of the serious health risks posed by the unauthorised substance Melanotan 2, often described as a self tanning aid. We strongly advise members of the public not to Avoid nasal tanning sprays or nasal tanners entirely. These products promise an all over tan without sun exposure but they are unregulated, can be unsafe, and contain potentially risky substances like Melanotan 2.