Ferroptosis and Intrinsic Drug induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. PDF) Erratum to: The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit Liver injury induced by paracetamol and challenges associated with intentional and unintentional use