Design, synthesis, and biological evaluation of nitroisoxazole containing spiro[pyrrolidin oxindole] derivatives as novel glutathione peroxidase 4 mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation ScienceDirect GPX4 independent ferroptosisa new strategy in disease's therapy Cell Death Discovery Glutathione Peroxidases: An Emerging and Promising Therapeutic Target for Pancreatic Cancer Treatment ML162