A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Glutathione Depletion in Mitochondrial Diseases Glutathione Reporter Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Acquired pyroglutamic acidosis due to long term dicloxacillin and paracetamol use BMJ Case Reports
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