TLK286 is activated by the enzyme glutathione S transferase (GST) P1 1. Download Scientific Diagram Glutathione S transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines British Journal of Cancer Studies of Glutathione Transferase P11 Bound to a Platinum(IV)Based Anticancer Compound Reveal the Molecular Basis of Its Activation Parker 2011 Chemistry A European Journal Wiley Online Library Glutathione S transferases P1 protects breast cancer cell from adriamycin induced cell death through promoting autophagy Cell Death & Differentiation
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glutathione s transferase p1 Glutathione-S-transferase P1–1 processing of TLK286 to active metabolites.