Endoscopic Imaging of Melanosis Coli Melanosis coli: Harmless pigmentation? A case control retrospective study of 657 cases PLOS One Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association M79.1 ICD 10 Code: Myalgia
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