Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Sex differences in glutathione metabolism and acetaminophen toxicity Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Sex differences in glutathione metabolism and acetaminophen toxicity