What is glutathione and why must we protect patient access to it? Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine how acetaminophen is broken down and metabolized! why you should not worry about glutathione depletion! #acetaminophen #glutathione #harvardmed #metabolism #medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.